Description
A pyrimidone that is uracil with methyl group substituents at positions 3 and 5.
Chemical properties
| Chemical formula | Net charge | Average mass |
|---|---|---|
| C6H8N2O2 | 0 | 140.140 |
Recommended notation
| Name | 3-methylthymine |
|---|---|
| Abbreviation | 3mT |
Nomenclature
| IUPAC | SMILES | InChI | InChIKey | Synonyms |
|---|---|---|---|---|
| 3,5-dimethylpyrimidine-2,4(1H,3H)-dione | O=C1N(C(=O)C(=CN1)C)C | InChI=1S/C6H8N2O2/c1-4-3-7-6(10)8(2)5(4)9/h3H,1-2H3,(H,7,10) | IIDONYMEGWHGRU-UHFFFAOYSA-N |
|
Nature
| Origin | Function | Functional detail |
Organisms
|
References |
|---|---|---|---|---|
| natural | damage | mutagenic | Rattus norvegicus |
Citations
- Blackburn, GM, et al. 1966. The photochemistry of 1-methylthymine and 3-methylthymine. Journal of the Chemical Society. Perkin Transactions 1. 15.
- Craddock, VM, et al. 1972. Analysis of DNA for the formation of 3-methylthymine after administration of dimethylnitrosamine. Chemico-biological Interactions. 4(3).
- Delaney, JC, et al. 2004. Mutagenesis, genotoxicity, and repair of 1-methyladenine, 3-alkylcytosines, 1-methylguanine, and 3-methylthymine in alkB Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 101(39).
- Den Engelse, L, et al. 1986. Formation and stability of alkylated pyrimidines and purines (including imidazole ring-opened 7-alkylguanine) and alkylphosphotriesters in liver DNA of adult rats treated with ethylnitrosourea or dimethylnitrosamine. Carcinogenesis. 7(3).