DNAmod: 3,N4-ethenocytosine

Chemical properties

Chemical formula	Net charge	Average mass
C6H5N3O	0	135.12340

3,<i>N</i><sup>4</sup>-ethenocytosine

Recommended notation

Name	3,N⁴-ethenocytosine
Abbreviation	ɛC

Nomenclature

IUPAC	SMILES	InChI	InChIKey	Synonyms
imidazo[1,2-c]pyrimidin-5(6H)-one	O=c1[nH]ccc2nccn12	InChI=1S/C6H5N3O/c10-6-8-2-1-5-7-3-4-9(5)6/h1-4H,(H,8,10)	GICKXGZWALFYHZ-UHFFFAOYSA-N	3,n(4)-ethanocytosine ethenocytosine

Nature

Origin	Function	Functional detail	Organisms	References
natural	damage	mutagenic	Escherichia coli Homo sapiens	Marnett, LJ, et al. 1993. Endogenous DNA adducts: potential and paradox. Chemical Research in Toxicology. 6(6). Saparbaev, M, et al. 1998. 3,N4-ethenocytosine, a highly mutagenic adduct, is a primary substrate for Escherichia coli double-stranded uracil-DNA glycosylase and human mismatch-specific thymine-DNA glycosylase. Proceedings of the National Academy of Sciences of the United States of America. 95(15).

Database references:

CHEBI:29147

Citations

Marnett, LJ, et al. 1993. Endogenous DNA adducts: potential and paradox. Chemical Research in Toxicology. 6(6).
Saparbaev, M, et al. 1998. 3,N4-ethenocytosine, a highly mutagenic adduct, is a primary substrate for Escherichia coli double-stranded uracil-DNA glycosylase and human mismatch-specific thymine-DNA glycosylase. Proceedings of the National Academy of Sciences of the United States of America. 95(15).