Hoffman research group
- Michael M. Hoffman
- Senior Scientist (principal investigator)
- Computational Biology and Medicine Program
- Princess Margaret Cancer Centre
- University Health Network
- Associate Professor (status-only)
- Computational Biology Group
- Department of Computer Science
- University of Toronto
We develop machine learning techniques to better understand chromatin biology. These models and algorithms transform high-dimensional functional genomics data into interpretable patterns and lead to new biological insight.
Publications
Software
- Segway: semi-automated genomic annotation
- Segtools: segmentation analysis and graphics
- Genomedata: efficient storage and retrieval
- Umap and Bismap: tools for quantifying mappability of the genome and methylome
- BEHST: biological enrichment of hidden sequence targets
- Virchip: predicting transcription factor binding by learning from the transcriptome
- PeaKO: finding transcription factor binding motifs using knockout controls
Databases
- DNAmod: the DNA modification database
Join the lab
People
Meet the team- Michael Hoffman
- Eric Roberts
- Luomeng Tan
- Mary Agopian
- Gergely Pap
- Yahan Zhang
- Natalia Mukhina
News
- 2025-09-02: Eric releases Genomedata 1.7.4
- 2025-08-18: Michael is an invited panelist speaking at the workshop panel on "Open Questions and Opportunities for AI in Genomics," organized by the Data Sciences Institute, University of Toronto.
- 2025-07-14: Mary is a recipient of the 2025-2026 Ontario Graduate Scholarship.
- 2025-06-26: Yahan is a recipient of the 2025-2026 Marathon of Hope Cancer Centres Network (MOHCCN) award.
- 2024-11-06: Michael is a commentator on a news story titled "Researchers rejoice: the Canadian Common CV’s days are numbered", on University Affairs.
- 2024-10-15: Michael is a co-author on a paper titled "LINE1 and PRC2 control nucleolar organization and repression of the 8C-state in human ESCs on Developmental Cell.
- News archive
Contact
- Twitter: @michaelhoffman
- LinkedIn: michaelmhoffman